Aldo-keto reductase

(Difference between revisions)

Revision as of 13:50, 28 December 2016

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 ==Structural highlights ==
-The active site of AKR1B10 contains the cofactor <scene name='49/491879/Cv/4'>NADP</scene> and a <scene name='49/491879/Cv/5'>polyfluorinated inhibitor</scene>.  <scene name='49/491879/Cv/6'>Tyr and His </scene>are part of the enzyme catalytic tetrad<ref>PMID:24598757</ref>. Water molecules are shown as red spheres.
+The active site of AKR1B10 contains the cofactor <scene name='49/491879/Cv/4'>NADP</scene> and a <scene name='49/491879/Cv/5'>polyfluorinated inhibitor</scene>. Water molecules are shown as red spheres.
+*<scene name='49/491879/Cv/6'>Tyr and His </scene>are part of the enzyme catalytic tetrad<ref>PMID:24598757</ref>.
+*<scene name='49/491879/Cv/7'>NADP and polyfluorinated inhibitor are situated in the tunnel</scene>.
 ==3D structures of aldo-keto reductase==