1r7r
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= VCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= VCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7r OCA], [http://www.ebi.ac.uk/pdbsum/1r7r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r7r RCSB]</span> | ||
}} | }} | ||
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[[Category: Pye, V E.]] | [[Category: Pye, V E.]] | ||
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
| - | [[Category: ADP]] | ||
[[Category: aaa]] | [[Category: aaa]] | ||
[[Category: cdc48]] | [[Category: cdc48]] | ||
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[[Category: vcp]] | [[Category: vcp]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:24:27 2008'' |
Revision as of 20:24, 30 March 2008
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| , resolution 3.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | VCP (Mus musculus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The crystal structure of murine p97/VCP at 3.6A
Overview
p97/VCP is a member of the AAA ATPase family and has roles in both membrane fusion and ubiquitin dependent protein degradation. Here, we present a 3.6A crystal structure of murine p97 in which D2 domain has been modelled as poly-alanine and the remaining approximately 100 residues are absent. The resulting structure illustrates a head-to-tail packing arrangement of the two p97 AAA domains in a natural hexameric state with D1 ADP bound and D2 nucleotide free. The head-to-tail packing arrangement observed in this structure is in contrast to our previously predicted tail-to-tail packing model. The linker between the D1 and D2 domains is partially disordered, suggesting a flexible nature. Normal mode analysis of the crystal structure suggests anti-correlated motions and distinct conformational states of the two AAA domains.
About this Structure
1R7R is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1R7R with [AAA+ Proteases]. Full crystallographic information is available from OCA.
Reference
The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:14643202
Page seeded by OCA on Sun Mar 30 23:24:27 2008
Categories: AAA+ Proteases | Mus musculus | Single protein | Beuron, F. | Briggs, L C. | Flynn, T C. | Freemont, P S. | Huyton, T. | Kondo, H. | Ma, J. | Pye, V E. | Zhang, X. | Aaa | Cdc48 | P97 | Vcp
