5b1z
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Bcl-xL in complex with HBx-BH3 motif== | |
| - | + | <StructureSection load='5b1z' size='340' side='right' caption='[[5b1z]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b1z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1z OCA], [http://pdbe.org/5b1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1z RCSB], [http://www.ebi.ac.uk/pdbsum/5b1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1z ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Yuan, Y | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/I3XMW8_HBV I3XMW8_HBV]] Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with host factors.[RuleBase:RU361181] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Yuan, Y A]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Bcl-xl]] | ||
| + | [[Category: Hbv replication]] | ||
| + | [[Category: Hbx]] | ||
Revision as of 16:19, 2 January 2017
Crystal structure of Bcl-xL in complex with HBx-BH3 motif
| |||||||||||
Categories: Yuan, Y A | Apoptosis | Bcl-xl | Hbv replication | Hbx
