5kzq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid== | |
| - | + | <StructureSection load='5kzq' size='340' side='right' caption='[[5kzq]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kzq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KZQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YS:(1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>6YS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kzn|5kzn]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzq OCA], [http://pdbe.org/5kzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzq RCSB], [http://www.ebi.ac.uk/pdbsum/5kzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Antonysamy, S]] | ||
| + | [[Category: Atwell, S]] | ||
| + | [[Category: Barberis, M]] | ||
| + | [[Category: Bedwell, D]] | ||
| + | [[Category: Blanco, M J]] | ||
| + | [[Category: Bradley, C]] | ||
| + | [[Category: Britton, T]] | ||
| + | [[Category: Bures, M]] | ||
| + | [[Category: Carpintero, M]] | ||
| + | [[Category: Catlow, J]] | ||
| + | [[Category: Chappell, M D]] | ||
| + | [[Category: Condon, B]] | ||
| + | [[Category: Conners, K]] | ||
| + | [[Category: Diego, J E.de]] | ||
| + | [[Category: Dressman, B A]] | ||
| + | [[Category: Erickson, J A]] | ||
| + | [[Category: Fivush, A M]] | ||
| + | [[Category: Garcia-Cerrada, S]] | ||
| + | [[Category: Groshong, C]] | ||
| + | [[Category: Heinz, B A]] | ||
| + | [[Category: Jaramillo, C]] | ||
| + | [[Category: Koss, J W]] | ||
| + | [[Category: Li, R]] | ||
| + | [[Category: Li, X]] | ||
| + | [[Category: MacEwan, I]] | ||
| + | [[Category: Matt, J]] | ||
| + | [[Category: Mayhugh, D]] | ||
| + | [[Category: Mitch, C H]] | ||
| + | [[Category: Monn, J A]] | ||
| + | [[Category: Ornstein, P]] | ||
| + | [[Category: Overshiner, C]] | ||
| + | [[Category: Quimby, S J]] | ||
| + | [[Category: Schkeryantz, J M]] | ||
| + | [[Category: Seidel, W]] | ||
| + | [[Category: Smith, S C]] | ||
| + | [[Category: Soriano, J F]] | ||
| + | [[Category: Swanson, S]] | ||
| + | [[Category: Tripp, A E]] | ||
| + | [[Category: Tromiczak, E G]] | ||
| + | [[Category: Vetman, T]] | ||
| + | [[Category: Wafford, K A]] | ||
| + | [[Category: Wang, J]] | ||
| + | [[Category: Wang, X S]] | ||
| + | [[Category: Wasserman, S R]] | ||
| + | [[Category: Witkin, J M]] | ||
| + | [[Category: Zhang, A]] | ||
| + | [[Category: Antagonist]] | ||
| + | [[Category: Antidepressent]] | ||
| + | [[Category: Mglur2]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 16:25, 2 January 2017
Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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Categories: Antonysamy, S | Atwell, S | Barberis, M | Bedwell, D | Blanco, M J | Bradley, C | Britton, T | Bures, M | Carpintero, M | Catlow, J | Chappell, M D | Condon, B | Conners, K | Diego, J E.de | Dressman, B A | Erickson, J A | Fivush, A M | Garcia-Cerrada, S | Groshong, C | Heinz, B A | Jaramillo, C | Koss, J W | Li, R | Li, X | MacEwan, I | Matt, J | Mayhugh, D | Mitch, C H | Monn, J A | Ornstein, P | Overshiner, C | Quimby, S J | Schkeryantz, J M | Seidel, W | Smith, S C | Soriano, J F | Swanson, S | Tripp, A E | Tromiczak, E G | Vetman, T | Wafford, K A | Wang, J | Wang, X S | Wasserman, S R | Witkin, J M | Zhang, A | Antagonist | Antidepressent | Mglur2 | Signaling protein
