5kqs
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqs OCA], [http://pdbe.org/5kqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kqs RCSB], [http://www.ebi.ac.uk/pdbsum/5kqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqs OCA], [http://pdbe.org/5kqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kqs RCSB], [http://www.ebi.ac.uk/pdbsum/5kqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify features of ZIKV NS5 methyltransferase that lend to structure-based antiviral drug discovery. Specifically, SAM analogs with functionalities on the Cbeta atom of the methionine portion of the molecules that occupy the RNA binding tunnel may provide better specificity relative to human RNA methyltransferases. | ||
| + | |||
| + | Structures of NS5 Methyltransferase from Zika Virus.,Coloma J, Jain R, Rajashankar KR, Garcia-Sastre A, Aggarwal AK Cell Rep. 2016 Sep 20;16(12):3097-102. doi: 10.1016/j.celrep.2016.08.091. Epub, 2016 Sep 12. PMID:27633330<ref>PMID:27633330</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5kqs" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:43, 4 January 2017
Structure of NS5 methyltransferase from Zika virus bound to S-adenosylmethionine and 7-methyl-guanosine-5'-diphosphate
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Categories: Aggarwal, A K | Coloma, J | Jain, R | Rajashankar, K R | Flavivirus | Methyltransferase | Ns5 | Transferase | Zika
