1reg
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1reg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reg OCA], [http://www.ebi.ac.uk/pdbsum/1reg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1reg RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1REG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1REG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REG OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution., Kang C, Chan R, Berger I, Lockshin C, Green L, Gold L, Rich A, Science. 1995 May 26;268(5214):1170-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7761833 7761833] | Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution., Kang C, Chan R, Berger I, Lockshin C, Green L, Gold L, Rich A, Science. 1995 May 26;268(5214):1170-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7761833 7761833] | ||
| - | [[Category: | + | [[Category: Enterobacteria phage t4]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kang, C.]] | [[Category: Kang, C.]] | ||
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[[Category: translational regulator protein]] | [[Category: translational regulator protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:27:01 2008'' |
Revision as of 20:27, 30 March 2008
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| , resolution 1.9Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION
Overview
The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs. The crystal structure of regA was determined at 1.9 A resolution; the protein was shown to have an alpha-helical core and two regions with antiparallel beta sheets. One of these beta sheets has four antiparallel strands and has some sequence homology to RNP-1 and RNP-2, which are believed to be RNA-binding motifs and are found in a number of known RNA-binding proteins. Structurally guided mutants may help to uncover the basis for this variety of RNA interaction.
About this Structure
1REG is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.
Reference
Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution., Kang C, Chan R, Berger I, Lockshin C, Green L, Gold L, Rich A, Science. 1995 May 26;268(5214):1170-3. PMID:7761833
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