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4pok
From Proteopedia
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==Crystal structures of thioredoxin with mesna at 2.5A resolution== | ==Crystal structures of thioredoxin with mesna at 2.5A resolution== | ||
<StructureSection load='4pok' size='340' side='right' caption='[[4pok]], [[Resolution|resolution]] 2.52Å' scene=''> | <StructureSection load='4pok' size='340' side='right' caption='[[4pok]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COM:1-THIOETHANESULFONIC+ACID'>COM</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pol|4pol]], [[4pom|4pom]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pol|4pol]], [[4pom|4pom]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pok RCSB], [http://www.ebi.ac.uk/pdbsum/4pok PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pok OCA], [http://pdbe.org/4pok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pok RCSB], [http://www.ebi.ac.uk/pdbsum/4pok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pok ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> | [[http://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN]] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> | ||
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| + | ==See Also== | ||
| + | *[[Thioredoxin|Thioredoxin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:17, 4 January 2017
Crystal structures of thioredoxin with mesna at 2.5A resolution
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