User:Camille Zumstein/Sandbox
From Proteopedia
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The main partners of interaction are [https://en.wikipedia.org/wiki/Calmodulin Calmodulin], | The main partners of interaction are [https://en.wikipedia.org/wiki/Calmodulin Calmodulin], | ||
| - | Calcineurin is inhibited by the immunosuppressive drugs tacrolismus (FK506) or cyclosporine A (CsA). CsA and FK506 conduct their therapeutic role thought binding to the [https://en.wikipedia.org/wiki/Immunophilins immunophilins] cyclophilin and FK506 binding protein (FK506BP) respectively. The complexes CsA-cyclophilin and FK506-FK506BP bind then to calcineurin in a calcium-dependent manner thus inhibiting its phosphatase activity. Therefore the addition of these drugs to | + | Calcineurin is inhibited by the immunosuppressive drugs tacrolismus (FK506) or cyclosporine A (CsA). CsA and FK506 conduct their therapeutic role thought binding to the [https://en.wikipedia.org/wiki/Immunophilins immunophilins] cyclophilin and FK506 binding protein (FK506BP) respectively. The complexes CsA-cyclophilin and FK506-FK506BP bind then to calcineurin in a calcium-dependent manner thus inhibiting its phosphatase activity. Therefore the addition of these drugs to lymphocytes T prevent NFAT translocation to the nucleus and the subsequent activation its target gene<ref>https://www.ncbi.nlm.nih.gov/pubmed/8811062</ref>. |
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== Related health defects == | == Related health defects == | ||
| + | '''Rheumatic diseases (arthritis)'''': | ||
| + | '''Schizophrenia''': | ||
| + | '''Diabetes''': | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:41, 7 January 2017
==Your Heading Here (maybe something like 'Structure')== 2
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ http://www.uniprot.org/uniprot/P63329
- ↑ http://www.sciencedirect.com/science/article/pii/S0898656813002702
- ↑ http://www.rcsb.org/pdb/explore/explore.do?structureId=4IL1
- ↑ https://www.ncbi.nlm.nih.gov/pubmed/8811062
