User:Charli Barbet/Sandbox

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Grb2 protein has a very well characterized structure. Composed of 217 amino acids structured in B sheets and alpha helices.
Grb2 protein has a very well characterized structure. Composed of 217 amino acids structured in B sheets and alpha helices.
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<nowiki>The protein has three main domains:
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The protein has three main domains:
- A SH3 domain (1-58) long of 58 amino acids
- A SH3 domain (1-58) long of 58 amino acids
- A SH2 domain (60-152) long od 93 amino acids
- A SH2 domain (60-152) long od 93 amino acids
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- Another SH3 domain (156-215) 60 amino acids long</nowiki>
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- Another SH3 domain (156-215) 60 amino acids long
SH2 DOMAIN:
SH2 DOMAIN:
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The functional isoform Grb2 is involved in several cellular functions detailed below.
The functional isoform Grb2 is involved in several cellular functions detailed below.
On one hand, the SH2 domain recognizes phosphorylated residues which are mainly tyrosines. The recognized tyrosines present a caracteristic motif for recognition : NH2-pYXNX-COOH.
On one hand, the SH2 domain recognizes phosphorylated residues which are mainly tyrosines. The recognized tyrosines present a caracteristic motif for recognition : NH2-pYXNX-COOH.
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- pY representing the phosphorylated tyrosine.
- pY representing the phosphorylated tyrosine.
- N for Asparagine
- N for Asparagine

Revision as of 10:29, 12 January 2017

==Your Heading Here (maybe something like 'Structure')== 2

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Charli Barbet

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