BRCA
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''BRCA1''' and '''BRCA2''' or '''breast cancer type 1 susceptibility ...) |
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== Function == | == Function == | ||
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== Disease == | == Disease == | ||
Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers<ref>PMID:20301425</ref>. | Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers<ref>PMID:20301425</ref>. | ||
| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 18:05, 12 January 2017
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3D structures of BRCA1
4ofb, 4y18, 4y2g, 4u4a, 4jlu, 4ifi, 4igk, 3k0h, 3k0k, 3coj, 1y98, 1t15, 1t29, 1t2v - hBRCA1 BRCT1 domain + peptide inhibitor - human
3pxa, 3pxb, 3pxc, 3pxd, 3pxe, 3k15, 3k16 - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor
1jnx - hBRCA1 BRCT domain
2ing, 1t2u, 1n5o - hBRCA1 BRCT1 domain (mutant)
1oqa - hBRCA1 BRCT-C domain - NMR
1l0b - BRCA1 BRCT domain - rat
2n9e - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR
4mkf, 4mkg - hBRCA1 SUMO-interacting motif - NMR
1jm7 - hBRCA1 Ring domain + BARD1 ring domian - NMR
References
- ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
