1rji
From Proteopedia
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rji OCA], [http://www.ebi.ac.uk/pdbsum/1rji PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rji RCSB]</span> | ||
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[[Category: beta sheet]] | [[Category: beta sheet]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:28:59 2008'' |
Revision as of 20:29, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch
Overview
Scorpion venom is a rich source of bioactive peptides. From the venom of Chinese scorpion Buthus martensi Karsch (BmK), a novel short chain peptide BmKX of 31-amino acid residues was purified, and its amino acid sequence and gene structure were determined. The gene of BmKX was composed of two exons interrupted by an 86-bp intron at the codon-7 upstream of the mature peptide. Although its gene structure is similar to those of other known scorpion toxins, its amino acid sequence, especially the cysteine framework, is different from those of all other known subfamilies of short-chain scorpion toxins. The solution structure of BmKX, determined with two-dimensional NMR spectroscopy, shows that BmKX also forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins, consisting of a short 3(10)-helix and a two-stranded antiparallel beta-sheet, and the short N-terminal segment forms a pseudo-strand of the beta-sheet. However, the orientation between the helix and the beta-sheet is significantly different from the others, which might be the reason for its unique but still unclear physiological function.
About this Structure
1RJI is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination., Wang CG, Cai Z, Lu W, Wu J, Xu Y, Shi Y, Chi CW, Toxicon. 2005 Mar 1;45(3):309-19. Epub 2005 Jan 20. PMID:15683869
Page seeded by OCA on Sun Mar 30 23:28:59 2008
Categories: Single protein | Cai, Z. | Chi, C W. | Shi, Y. | Wang, C G. | Wu, J. | Xu, Y. | 3-10 helix | Beta sheet
