5gn1

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'''Unreleased structure'''
 
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The entry 5gn1 is ON HOLD until Paper Publication
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==Crystal structure of the C-terminal part of Fun30 ATPase domain==
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<StructureSection load='5gn1' size='340' side='right' caption='[[5gn1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gn1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GN1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gn1 OCA], [http://pdbe.org/5gn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gn1 RCSB], [http://www.ebi.ac.uk/pdbsum/5gn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gn1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/FUN30_YEAST FUN30_YEAST]] DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs, facilitating single-stranded DNA (ssDNA) production by the EXO1 and SGS1 machinery. Promotes gene silencing at heterochromatin by regulating the chromatin structure within or around silent loci. Also required for heterochromatin organization at centromeres.<ref>PMID:19956593</ref> <ref>PMID:20075079</ref> <ref>PMID:22960743</ref> <ref>PMID:22960744</ref> <ref>PMID:23007155</ref> <ref>PMID:23028372</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: DNA helicase]]
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[[Category: Jiang, T]]
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[[Category: Liu, L]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Reca]]
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[[Category: Remodeler]]

Revision as of 16:25, 18 January 2017

Crystal structure of the C-terminal part of Fun30 ATPase domain

5gn1, resolution 1.95Å

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