5hfe
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in complex with a C-terminal peptide derived from CRIPT== |
| - | + | <StructureSection load='5hfe' size='340' side='right' caption='[[5hfe]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hfe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HFE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1be9|1be9]], [[5hdy|5hdy]], [[5heb|5heb]], [[5hed|5hed]], [[5het|5het]], [[5hey|5hey]], [[5hf1|5hf1]], [[5hf4|5hf4]], [[5hfb|5hfb]], [[5hfc|5hfc]], [[5hfd|5hfd]], [[5hff|5hff]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfe OCA], [http://pdbe.org/5hfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfe RCSB], [http://www.ebi.ac.uk/pdbsum/5hfe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfe ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> [[http://www.uniprot.org/uniprot/CRIPT_RAT CRIPT_RAT]] Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.<ref>PMID:10570482</ref> <ref>PMID:9581762</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Raman, A S]] | ||
| + | [[Category: Ranganathan, R]] | ||
| + | [[Category: White, K I]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Dhr]] | ||
| + | [[Category: Glgf]] | ||
| + | [[Category: Pdz]] | ||
| + | [[Category: Peptide binding protein]] | ||
| + | [[Category: Peptide-binding domain]] | ||
| + | [[Category: Synapse]] | ||
| + | [[Category: Synaptic density]] | ||
Revision as of 16:27, 18 January 2017
The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant) in complex with a C-terminal peptide derived from CRIPT
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