1rpa

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|PDB= 1rpa |SIZE=350|CAPTION= <scene name='initialview01'>1rpa</scene>, resolution 3.0&Aring;
|PDB= 1rpa |SIZE=350|CAPTION= <scene name='initialview01'>1rpa</scene>, resolution 3.0&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=TAR:D(-)-TARTARIC ACID'>TAR</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span>
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpa OCA], [http://www.ebi.ac.uk/pdbsum/1rpa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rpa RCSB]</span>
}}
}}
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[[Category: Lindqvist, Y.]]
[[Category: Lindqvist, Y.]]
[[Category: Schneider, G.]]
[[Category: Schneider, G.]]
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[[Category: NAG]]
 
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[[Category: TAR]]
 
[[Category: hydrolase(phosphoric monoester)]]
[[Category: hydrolase(phosphoric monoester)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:54:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:06 2008''

Revision as of 20:31, 30 March 2008


PDB ID 1rpa

Drag the structure with the mouse to rotate
, resolution 3.0Å
Ligands: , ,
Activity: Acid phosphatase, with EC number 3.1.3.2
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL STRUCTURE OF RAT ACID PHOSPHATASE IN COMPLEX WITH L(+) TARTRATE


Overview

The crystal structure of recombinant rat prostatic acid phosphatase in complex with the inhibitor L(+)-tartrate was determined to 3-A resolution with protein crystallographic methods. The inhibitor binds at the carboxyl end of the parallel strands of the alpha/beta domain. One of the carboxyl groups of the tartrate molecule interacts with the conserved residues Arg-11, His-12, and Arg-15, which form part of the phosphate binding site. Furthermore, the C2 and C3 hydroxyl groups interact with His-257 and Arg-79. The second carboxyl group is close to Arg-79 but makes no direct hydrogen bonds to the protein. A sequence comparison between tartrate-sensitive and -resistant acid phosphatases suggests that these enzymes have different three-dimensional structures.

About this Structure

1RPA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of rat acid phosphatase in complex with L(+)-tartrate., Lindqvist Y, Schneider G, Vihko P, J Biol Chem. 1993 Oct 5;268(28):20744-6. PMID:8407898

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