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5m5g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)== | |
| + | <StructureSection load='5m5g' size='340' side='right' caption='[[5m5g]], [[Resolution|resolution]] 2.27Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5m5g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M5G FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ch1|5ch1]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m5g OCA], [http://pdbe.org/5m5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m5g RCSB], [http://www.ebi.ac.uk/pdbsum/5m5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m5g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect. | ||
| - | + | Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".,Zhang Y, Justin N, Wilson JR, Gamblin SJ Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaf6236. PMID:28008037<ref>PMID:28008037</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5m5g" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gamblin, S]] | ||
| + | [[Category: Justin, N]] | ||
| + | [[Category: Wilson, J]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Repressive]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 16:33, 18 January 2017
Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)
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Categories: Gamblin, S | Justin, N | Wilson, J | Zhang, Y | Complex | Repressive | Transferase
