1rqf
From Proteopedia
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|PDB= 1rqf |SIZE=350|CAPTION= <scene name='initialview01'>1rqf</scene>, resolution 2.89Å | |PDB= 1rqf |SIZE=350|CAPTION= <scene name='initialview01'>1rqf</scene>, resolution 2.89Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span> |
|GENE= KC2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis]) | |GENE= KC2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1qf8|1QF8]], [[1jwh|1JWH]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rqf OCA], [http://www.ebi.ac.uk/pdbsum/1rqf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rqf RCSB]</span> | ||
}} | }} | ||
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[[Category: Pei, X Y.]] | [[Category: Pei, X Y.]] | ||
[[Category: Sayed, M F.]] | [[Category: Sayed, M F.]] | ||
| - | [[Category: UNK]] | ||
| - | [[Category: ZN]] | ||
[[Category: casein kinase beta subunit]] | [[Category: casein kinase beta subunit]] | ||
[[Category: cyclin-dependent kinase inhibitor]] | [[Category: cyclin-dependent kinase inhibitor]] | ||
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[[Category: zn finger]] | [[Category: zn finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:36 2008'' |
Revision as of 20:31, 30 March 2008
| |||||||
| , resolution 2.89Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | KC2B (Xenopus laevis) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Related: | 1QF8, 1JWH
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of CK2 beta subunit crystallized in the presence of a p21WAF1 peptide
Overview
A truncated form of the regulatory subunit of the protein kinase CK2beta (residues 1-178) has been crystallized in the presence of a fragment of the cyclin-dependent kinase inhibitor p21WAF1 (residues 46-65) and the structure solved at 2.9 A resolution by molecular replacement. The core of the CK2beta dimer shows a high structural similarity with that identified in previous structural analyses of the dimer and the holoenzyme. However, the electron density corresponding to the substrate-binding acidic loop (residues 55-64) indicates two conformations that differ from that of the holoenzyme structure [Niefind et al. (2001), EMBO J. 20, 5320-5331]. Difference electron density near the dimerization region in each of the eight protomers in the asymmetric unit is attributed to between one and eight amino-acid residues of a complexed fragment of p21WAF1. This binding site corresponds to the solvent-accessible part of the conserved zinc-finger motif.
About this Structure
1RQF is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.
Reference
Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop., Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1698-704. Epub, 2004 Sep 23. PMID:15388915
Page seeded by OCA on Sun Mar 30 23:31:36 2008
Categories: Non-specific serine/threonine protein kinase | Single protein | Xenopus laevis | Allende, J E. | Bertrand, L. | Blundell, T L. | Bolanos-Garcia, V M. | Dhanaraj, V. | Parisini, E. | Pei, X Y. | Sayed, M F. | Casein kinase beta subunit | Cyclin-dependent kinase inhibitor | Ser/thr protein kinase | Zn finger
