4rsu
From Proteopedia
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==Crystal structure of the light and hvem complex== | ==Crystal structure of the light and hvem complex== | ||
<StructureSection load='4rsu' size='340' side='right' caption='[[4rsu]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4rsu' size='340' side='right' caption='[[4rsu]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j6g|4j6g]], [[4fhq|4fhq]], [[2aw2|2aw2]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j6g|4j6g]], [[4fhq|4fhq]], [[2aw2|2aw2]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rsu RCSB], [http://www.ebi.ac.uk/pdbsum/4rsu PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsu OCA], [http://pdbe.org/4rsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rsu RCSB], [http://www.ebi.ac.uk/pdbsum/4rsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rsu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref> | [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. [[http://www.uniprot.org/uniprot/TNR14_HUMAN TNR14_HUMAN]] Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.<ref>PMID:8898196</ref> | ||
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| + | ==See Also== | ||
| + | *[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:20, 18 January 2017
Crystal structure of the light and hvem complex
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Categories: Almo, S C | Bonanno, J B | Himmel, D | IFN, Atoms-to-Animals:.The Immune Function Network | Liu, W | Structural genomic | Nathenson, S G | Ramagoal, U A | Atoms-to-animals: the immune function network | Cell membrane | Cysteine rich domain | Cytokine | Ifn | Immune system | Immunity | Jelly-roll fold | Membrane | N-glycosylation | Nysgrc | PSI, Protein structure initiative | Psi-biology | Research consortium | Secreted | Secreted protein | Signaling
