4q2v
From Proteopedia
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==Crystal Structure of Ricin A chain complexed with Baicalin inhibitor== | ==Crystal Structure of Ricin A chain complexed with Baicalin inhibitor== | ||
<StructureSection load='4q2v' size='340' side='right' caption='[[4q2v]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4q2v' size='340' side='right' caption='[[4q2v]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XE:5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-CHROMEN-7-YL+BETA-D-GLUCOPYRANOSIDURONIC+ACID'>0XE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XE:5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-CHROMEN-7-YL+BETA-D-GLUCOPYRANOSIDURONIC+ACID'>0XE</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q2v RCSB], [http://www.ebi.ac.uk/pdbsum/4q2v PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2v OCA], [http://pdbe.org/4q2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q2v RCSB], [http://www.ebi.ac.uk/pdbsum/4q2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q2v ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
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| + | ==See Also== | ||
| + | *[[Ricin|Ricin]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 17:23, 18 January 2017
Crystal Structure of Ricin A chain complexed with Baicalin inhibitor
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