5ckq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CUB1-EGF-CUB2 domains of rat MASP-1== | |
| - | + | <StructureSection load='5ckq' size='340' side='right' caption='[[5ckq]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ckq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CKQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ckq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ckq OCA], [http://pdbe.org/5ckq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ckq RCSB], [http://www.ebi.ac.uk/pdbsum/5ckq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ckq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MASP1_RAT MASP1_RAT]] Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Furze, C M]] | ||
[[Category: Gor, J]] | [[Category: Gor, J]] | ||
| - | [[Category: Wright, D.W]] | ||
| - | [[Category: Perkins, S.J]] | ||
[[Category: Nan, R]] | [[Category: Nan, R]] | ||
| - | [[Category: | + | [[Category: Perkins, S J]] |
[[Category: Wallis, R]] | [[Category: Wallis, R]] | ||
| + | [[Category: Wright, D W]] | ||
| + | [[Category: Complement]] | ||
| + | [[Category: Cub1-egf-cub2]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lectin pathway]] | ||
| + | [[Category: Serine protease]] | ||
Revision as of 00:36, 19 January 2017
CUB1-EGF-CUB2 domains of rat MASP-1
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Categories: Furze, C M | Gor, J | Nan, R | Perkins, S J | Wallis, R | Wright, D W | Complement | Cub1-egf-cub2 | Hydrolase | Lectin pathway | Serine protease
