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5fql
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Insights into Hunter syndrome from the structure of iduronate-2- sulfatase== | |
| - | + | <StructureSection load='5fql' size='340' side='right' caption='[[5fql]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FQL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALS:(3S)-3-(SULFOOXY)-L-SERINE'>ALS</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iduronate-2-sulfatase Iduronate-2-sulfatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.6.13 3.1.6.13] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fql OCA], [http://pdbe.org/5fql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fql RCSB], [http://www.ebi.ac.uk/pdbsum/5fql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fql ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Mucopolysaccharidosis type 2, attenuated form;Mucopolysaccharidosis type 2, severe form. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDS_HUMAN IDS_HUMAN]] Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Iduronate-2-sulfatase]] | ||
| + | [[Category: Bunkoczi, G]] | ||
| + | [[Category: Deane, J E]] | ||
[[Category: Demydchuk, M]] | [[Category: Demydchuk, M]] | ||
| + | [[Category: Hill, C H]] | ||
| + | [[Category: Marchesan, D]] | ||
| + | [[Category: Read, R J]] | ||
| + | [[Category: Stein, P E]] | ||
[[Category: Zhou, A]] | [[Category: Zhou, A]] | ||
| - | [[Category: | + | [[Category: Hunter syndrome]] |
| - | [[Category: | + | [[Category: Hydrolase]] |
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Revision as of 00:37, 19 January 2017
Insights into Hunter syndrome from the structure of iduronate-2- sulfatase
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