5hf2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175)== | |
| - | + | <StructureSection load='5hf2' size='340' side='right' caption='[[5hf2]], [[Resolution|resolution]] 1.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hf2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HF2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U75:4-[3-[3-[2,4-BIS(AZANYL)-6-ETHYL-PYRIMIDIN-5-YL]PROP-2-YNYL]-5-METHOXY-PHENYL]BENZOIC+ACID'>U75</scene>, <scene name='pdbligand=XNP:TRICYCLIC+NADPH'>XNP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xec|4xec]], [[5hf0|5hf0]]</td></tr> |
| - | [[Category: Anderson, A | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> |
| - | [[Category: Reeve, S | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hf2 OCA], [http://pdbe.org/5hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5hf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hf2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dihydrofolate reductase]] | ||
| + | [[Category: Anderson, A C]] | ||
| + | [[Category: Reeve, S M]] | ||
| + | [[Category: Antibiotic]] | ||
| + | [[Category: Nadph]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Propargyl-linked antifolate]] | ||
Current revision
Staphylococcus aureus Dihydrofolate Reductase complexed with cyclized alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1175)
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