5hjz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of M. tuberculosis MazF-mt1 (Rv2801c) in complex with RNA== | |
| - | + | <StructureSection load='5hjz' size='340' side='right' caption='[[5hjz]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hjz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HJZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DU:2-DEOXYURIDINE-5-MONOPHOSPHATE'>DU</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hkc|5hkc]], [[5hk0|5hk0]], [[5hk3|5hk3]]</td></tr> |
| - | [[Category: Yen, T | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hjz OCA], [http://pdbe.org/5hjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hjz RCSB], [http://www.ebi.ac.uk/pdbsum/5hjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hjz ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAZF9_MYCTU MAZF9_MYCTU]] Toxic component of a type II toxin-antitoxin (TA) module. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene (PubMed:25608501). In E.coli expression with non-cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin.<ref>PMID:16611633</ref> <ref>PMID:19016878</ref> <ref>PMID:20011113</ref> <ref>PMID:20876537</ref> <ref>PMID:25608501</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brennan, R G]] | ||
| + | [[Category: Yen, T J]] | ||
| + | [[Category: Hydrolase-rna complex]] | ||
| + | [[Category: Mazf]] | ||
| + | [[Category: Toxin-antitoxin system]] | ||
Revision as of 00:41, 19 January 2017
Structure of M. tuberculosis MazF-mt1 (Rv2801c) in complex with RNA
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