1rsy
From Proteopedia
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|PDB= 1rsy |SIZE=350|CAPTION= <scene name='initialview01'>1rsy</scene>, resolution 1.9Å | |PDB= 1rsy |SIZE=350|CAPTION= <scene name='initialview01'>1rsy</scene>, resolution 1.9Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsy OCA], [http://www.ebi.ac.uk/pdbsum/1rsy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rsy RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Sprang, S R.]] | [[Category: Sprang, S R.]] | ||
[[Category: Sutton, R B.]] | [[Category: Sutton, R B.]] | ||
| - | [[Category: SO4]] | ||
[[Category: calcium/phospholipid binding protein]] | [[Category: calcium/phospholipid binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:26 2008'' |
Revision as of 20:32, 30 March 2008
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| , resolution 1.9Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD
Overview
C2 domains are regulatory sequence motifs that occur widely in nature. Synaptotagmin I, a synaptic vesicle protein involved in the Ca2+ regulation of exocytosis, contains two C2 domains, the first of which acts as a Ca2+ sensor. We now describe the three-dimensional structure of this C2 domain at 1.9 A resolution in both the Ca(2+)-bound and Ca(2+)-free forms. The C2 polypeptide forms an eight-stranded beta sandwich constructed around a conserved four-stranded motif designated as a C2 key. Ca2+ binds in a cup-shaped depression between two polypeptide loops located at the N- and C-termini of the C2-key motif.
About this Structure
1RSY is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold., Sutton RB, Davletov BA, Berghuis AM, Sudhof TC, Sprang SR, Cell. 1995 Mar 24;80(6):929-38. PMID:7697723
Page seeded by OCA on Sun Mar 30 23:32:26 2008
