User:Blandine Velut/Sandbox
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== HUMAN GMP SYNTHETASE == | == HUMAN GMP SYNTHETASE == | ||
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| + | An ample supply of nucleotides is essential for many life processes, including cell maturation, cell division and transmission of the genetic information. Indeed, nucleotides are the activated precursors of nucleic acids, but they also are major energy carriers, and precursors for the synthesis of nucleotide cofactors. Among these molecules is the guanosine monophosphate (GMP), also known as 5'-guanidylic acid or guanylic acid, a nucleotide that is used as a monomer in RNA. Like other nucleotides, GMP can be synthesized by 2 main pathways : de novo pathway and salvage pathway. De novo synthesis of nucleotide involves several enzymatic reaction and enzymes. Here, we will focus on the final step of the process, which is catalyzed by a glutamine amidotransferase called '''GMP synthetase''' (GMPS; E.C. 6.3.5.2). This enzyme belongs to the family of ligases, and catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP. | ||
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<StructureSection load='2vxo' size='340' side='right' caption='[[2vxo]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2vxo' size='340' side='right' caption='[[2vxo]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
Revision as of 14:35, 24 January 2017
2vxo
HUMAN GMP SYNTHETASE
An ample supply of nucleotides is essential for many life processes, including cell maturation, cell division and transmission of the genetic information. Indeed, nucleotides are the activated precursors of nucleic acids, but they also are major energy carriers, and precursors for the synthesis of nucleotide cofactors. Among these molecules is the guanosine monophosphate (GMP), also known as 5'-guanidylic acid or guanylic acid, a nucleotide that is used as a monomer in RNA. Like other nucleotides, GMP can be synthesized by 2 main pathways : de novo pathway and salvage pathway. De novo synthesis of nucleotide involves several enzymatic reaction and enzymes. Here, we will focus on the final step of the process, which is catalyzed by a glutamine amidotransferase called GMP synthetase (GMPS; E.C. 6.3.5.2). This enzyme belongs to the family of ligases, and catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP.
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
