5u4w
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4w OCA], [http://pdbe.org/5u4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4w RCSB], [http://www.ebi.ac.uk/pdbsum/5u4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4w ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u4w OCA], [http://pdbe.org/5u4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u4w RCSB], [http://www.ebi.ac.uk/pdbsum/5u4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u4w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The current Zika virus (ZIKV) epidemic is characterized by severe pathogenicity in both children and adults. Sequence changes in ZIKV since its first isolation are apparent when pre-epidemic strains are compared with those causing the current epidemic. However, the residues that are responsible for ZIKV pathogenicity are largely unknown. Here we report the cryo-electron microscopy (cryo-EM) structure of the immature ZIKV at 9-A resolution. The cryo-EM map was fitted with the crystal structures of the precursor membrane and envelope glycoproteins and was shown to be similar to the structures of other known immature flaviviruses. However, the immature ZIKV contains a partially ordered capsid protein shell that is less prominent in other immature flaviviruses. Furthermore, six amino acids near the interface between pr domains at the top of the spikes were found to be different between the pre-epidemic and epidemic ZIKV, possibly influencing the composition and structure of the resulting viruses. | ||
| + | |||
| + | Structure of the immature Zika virus at 9 A resolution.,Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG Nat Struct Mol Biol. 2017 Jan 9. doi: 10.1038/nsmb.3352. PMID:28067914<ref>PMID:28067914</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5u4w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 16:11, 25 January 2017
Cryo-EM Structure of Immature Zika Virus
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Categories: Zika virus | Buda, G | Jiang, W | Klose, T | Kuhn, R J | Miller, A S | Prasad, V Mangala | Rossmann, M G | Sirohi, D | Immature zika virus | Viral protein | Virus
