5h4i
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4i OCA], [http://pdbe.org/5h4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h4i RCSB], [http://www.ebi.ac.uk/pdbsum/5h4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4i ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4i OCA], [http://pdbe.org/5h4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h4i RCSB], [http://www.ebi.ac.uk/pdbsum/5h4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Zika virus (ZIKV) has rapidly emerged as a global public health concern. Viral NS2B-NS3 protease processes viral polyprotein and is essential for the virus replication, making it an attractive antiviral drug target. We report crystal structures at 1.58-angstrom resolution of the unlinked NS2B-NS3 protease from ZIKV as free enzyme and bound to a peptide reversely oriented at the active site. The unlinked NS2B-NS3 protease adopts a closed conformation in which NS2B engages NS3 to form an empty substrate-binding site. A second protease in the same crystal binds to the residues K14K15G16E17 from the neighboring NS3 in reverse orientation, resisting proteolysis. These features of ZIKV NS2B-NS3 protease may accelerate the discovery of structure-based antiviral drugs against ZIKV and related pathogenic flaviviruses. | ||
| + | |||
| + | Crystal structure of unlinked NS2B-NS3 protease from Zika virus.,Zhang Z, Li Y, Loh YR, Phoo WW, Hung AW, Kang C, Luo D Science. 2016 Dec 23;354(6319):1597-1600. doi: 10.1126/science.aai9309. Epub 2016, Dec 8. PMID:27940580<ref>PMID:27940580</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5h4i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 16:30, 25 January 2017
Unlinked NS2B-NS3 Protease from Zika Virus in complex with a compound fragment
| |||||||||||
