5wth

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'''Unreleased structure'''
 
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The entry 5wth is ON HOLD until Paper Publication
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==Cryo-EM structure for Hepatitis A virus complexed with FAB==
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<StructureSection load='5wth' size='340' side='right' caption='[[5wth]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wth]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus], [http://en.wikipedia.org/wiki/Hepatovirus_a Hepatovirus a] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wte|5wte]], [[5wtf|5wtf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wth OCA], [http://pdbe.org/5wth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wth RCSB], [http://www.ebi.ac.uk/pdbsum/5wth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wth ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis A virus (HAV) infects approximately 1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention.
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Authors:
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Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.,Wang X, Zhu L, Dang M, Hu Z, Gao Q, Yuan S, Sun Y, Zhang B, Ren J, Kotecha A, Walter TS, Wang J, Fry EE, Stuart DI, Rao Z Proc Natl Acad Sci U S A. 2017 Jan 10. pii: 201616502. doi:, 10.1073/pnas.1616502114. PMID:28074040<ref>PMID:28074040</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5wth" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Hepatitis a virus]]
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[[Category: Hepatovirus a]]
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[[Category: Mus musculus]]
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[[Category: Dang, M]]
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[[Category: Fry, E E]]
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[[Category: Gao, Q]]
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[[Category: Hu, Z]]
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[[Category: Rao, Z]]
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[[Category: Ren, J]]
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[[Category: Stuart, D I]]
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[[Category: Sun, Y]]
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[[Category: Walter, T S]]
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[[Category: Wang, J]]
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[[Category: Wang, X]]
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[[Category: Yuan, S]]
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[[Category: Zhang, B]]
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[[Category: Zhu, L]]
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[[Category: Hav]]
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[[Category: Neutralizing mechanism]]
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[[Category: Receptor recognition]]
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[[Category: Viral entry]]
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[[Category: Virus]]

Revision as of 23:34, 25 January 2017

Cryo-EM structure for Hepatitis A virus complexed with FAB

5wth, resolution 4.20Å

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