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5h47
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of AOL complexed with 2-MeSe-Fuc== | |
| + | <StructureSection load='5h47' size='340' side='right' caption='[[5h47]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h47]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H47 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FSW:(2S,3S,4R,5S,6R)-6-METHOXY-2-METHYL-5-METHYLSELANYL-OXANE-3,4-DIOL'>FSW</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eo7|5eo7]], [[5eo8|5eo8]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h47 OCA], [http://pdbe.org/5h47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h47 RCSB], [http://www.ebi.ac.uk/pdbsum/5h47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h47 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Selenium-incorporated fucoses (seleno-fucoses) differing in the position of the seleno-substituent were synthesized and applied to the X-ray structural determination of a carbohydrate-lectin complex using single/multi-wavelength anomalous dispersion (SAD/MAD) phasing. The hydroxyl groups at the C-1, -2, -3 and -4 position of fucose were individually substituted with a methylseleno group via a transacetalization reaction using MeSeCH2OBn or by an SN2 reaction with TolSe- equivalents to afford the corresponding MeSe-fucose. The three-dimensional structures of a fucose-binding lectin complexed with several of these MeSe-fucoses have been determined by SAD/MAD phasing by utilizing the diffraction of selenium in the bound MeSe-fucoses. | ||
| - | + | Synthesis of seleno-fucose compounds and their application to the X-ray structural determination of carbohydrate-lectin complexes using single/multi-wavelength anomalous dispersion phasing.,Shimabukuro J, Makyio H, Suzuki T, Nishikawa Y, Kawasaki M, Imamura A, Ishida H, Ando H, Kato R, Kiso M Bioorg Med Chem. 2016 Dec 19. pii: S0968-0896(16)31172-5. doi:, 10.1016/j.bmc.2016.12.021. PMID:28041800<ref>PMID:28041800</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5h47" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kato, R]] | ||
[[Category: Makyio, H]] | [[Category: Makyio, H]] | ||
[[Category: Nishikawa, Y]] | [[Category: Nishikawa, Y]] | ||
| - | [[Category: | + | [[Category: Aspergillus oryzae]] |
| + | [[Category: Lectin]] | ||
| + | [[Category: Phaing]] | ||
| + | [[Category: Seleno-fucose]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 23:35, 25 January 2017
Crystal structure of AOL complexed with 2-MeSe-Fuc
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