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5h3o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a eukaryotic cyclic nucleotide-gated channel== | |
| - | + | <StructureSection load='5h3o' size='340' side='right' caption='[[5h3o]], [[Resolution|resolution]] 3.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h3o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H3O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h3o OCA], [http://pdbe.org/5h3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h3o RCSB], [http://www.ebi.ac.uk/pdbsum/5h3o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h3o ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CNG_CAEEL CNG_CAEEL]] Required for normal thermosensation and chemosensation sensory behavior (PubMed:8893027). Required, downstream of receptor-type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons (PubMed:21173231). Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons (PubMed:23664973). Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation (PubMed:9486798). In ASI and ASJ sensory neurons, controls behavioral response to P.aeruginosa by up-regulating the transcription of daf-7, a member of the TGF-beta family (PubMed:25303524). In AWB and AWC sensory neurons, mediates the recognition of food oders which subsequently allows for the detection of preferred food sources (PubMed:25009271).<ref>PMID:21173231</ref> <ref>PMID:23664973</ref> <ref>PMID:25009271</ref> <ref>PMID:25303524</ref> <ref>PMID:8893027</ref> <ref>PMID:9486798</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gong, Y]] | ||
| + | [[Category: Li, H]] | ||
| + | [[Category: Li, M]] | ||
| + | [[Category: Li, X]] | ||
| + | [[Category: Michailidis, I]] | ||
| + | [[Category: Su, D]] | ||
| + | [[Category: Wang, S]] | ||
| + | [[Category: Yang, J]] | ||
| + | [[Category: Zhou, X]] | ||
| + | [[Category: Channel]] | ||
| + | [[Category: Cng]] | ||
| + | [[Category: Open state]] | ||
| + | [[Category: Tax-4]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 23:40, 25 January 2017
Structure of a eukaryotic cyclic nucleotide-gated channel
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Categories: Gong, Y | Li, H | Li, M | Li, X | Michailidis, I | Su, D | Wang, S | Yang, J | Zhou, X | Channel | Cng | Open state | Tax-4 | Transport protein
