5hq5

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'''Unreleased structure'''
 
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The entry 5hq5 is ON HOLD until Paper Publication
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==Crystal structure of fragment bound with Brd4==
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<StructureSection load='5hq5' size='340' side='right' caption='[[5hq5]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Chen, T.T., Xu, Y.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hq5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HQ5 FirstGlance]. <br>
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Description: Crystal structure of fragment bound with Brd4
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=64Q:7-METHYL-N-(O-TOLYL)-[1,2,4]TRIAZOLO[4,3-A]PYRIMIDIN-5-AMINE'>64Q</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hq6|5hq6]], [[5hq7|5hq7]]</td></tr>
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[[Category: Xu, Y.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hq5 OCA], [http://pdbe.org/5hq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hq5 RCSB], [http://www.ebi.ac.uk/pdbsum/5hq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hq5 ProSAT]</span></td></tr>
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[[Category: Chen, T.T]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chen, T T]]
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[[Category: Xu, Y C]]
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[[Category: Brd4]]
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[[Category: Transcription]]

Revision as of 23:42, 25 January 2017

Crystal structure of fragment bound with Brd4

5hq5, resolution 1.60Å

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