This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5lkl
From Proteopedia
(Difference between revisions)
m (Protected "5lkl" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of full-lengh CSFV NS3/4A== | |
| - | + | <StructureSection load='5lkl' size='340' side='right' caption='[[5lkl]], [[Resolution|resolution]] 3.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lkl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LKL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lkl OCA], [http://pdbe.org/5lkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lkl RCSB], [http://www.ebi.ac.uk/pdbsum/5lkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lkl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Rey, F A]] | ||
| + | [[Category: Tortorici, M A]] | ||
| + | [[Category: Viral protease/helicase with its cofactor]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 23:44, 25 January 2017
Crystal Structure of full-lengh CSFV NS3/4A
| |||||||||||
