5ws1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5ws1" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5ws1 is ON HOLD
+
==Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor==
-
 
+
<StructureSection load='5ws1' size='340' side='right' caption='[[5ws1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
Authors: Cao, R., Wang, Y.L., Zhou, J., Huang, N., Xu, B.L.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5ws1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WS1 FirstGlance]. <br>
-
Description: Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7U9:2-[(3R)-3-AZANYLPYRROLIDIN-1-YL]CARBONYL-1H-BENZIMIDAZOLE-4-CARBOXAMIDE'>7U9</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wrq|5wrq]], [[5wry|5wry]], [[5wrz|5wrz]], [[5ws0|5ws0]]</td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ws1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ws1 OCA], [http://pdbe.org/5ws1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ws1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ws1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ws1 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Cao, R]]
[[Category: Huang, N]]
[[Category: Huang, N]]
-
[[Category: Wang, Y.L]]
+
[[Category: Wang, Y L]]
-
[[Category: Cao, R]]
+
[[Category: Xu, B L]]
-
[[Category: Xu, B.L]]
+
[[Category: Zhou, J]]
[[Category: Zhou, J]]
 +
[[Category: Complex]]
 +
[[Category: Inhibitor]]
 +
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 23:48, 25 January 2017

Structure of human PARP1 catalytic domain bound to a benzoimidazole inhibitor

5ws1, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ws1"
Personal tools