3zcm
From Proteopedia
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==Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.== | ==Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.== | ||
<StructureSection load='3zcm' size='340' side='right' caption='[[3zcm]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3zcm' size='340' side='right' caption='[[3zcm]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3zcm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3zcm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aids_virus Aids virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZCM FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PX3:5-[[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL-PROP-2-ENYL-AMINO]METHYL]-1,3-BENZODIOXOLE-4-CARBOXYLIC+ACID'>PX3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PX3:5-[[[2-[(4-METHOXYPHENYL)METHYLCARBAMOYL]PHENYL]METHYL-PROP-2-ENYL-AMINO]METHYL]-1,3-BENZODIOXOLE-4-CARBOXYLIC+ACID'>PX3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zcm RCSB], [http://www.ebi.ac.uk/pdbsum/3zcm PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zcm OCA], [http://pdbe.org/3zcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zcm RCSB], [http://www.ebi.ac.uk/pdbsum/3zcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zcm ProSAT]</span></td></tr> |
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3zcm" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[HIV integrase|HIV integrase]] | ||
*[[Retroviral Integrase|Retroviral Integrase]] | *[[Retroviral Integrase|Retroviral Integrase]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Aids virus]] |
[[Category: Peat, T S]] | [[Category: Peat, T S]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 00:08, 26 January 2017
Small molecule inhibitors of the LEDGF site of HIV integrase identified by fragment screening and structure based design.
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