4ofh
From Proteopedia
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==Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis== | ==Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis== | ||
<StructureSection load='4ofh' size='340' side='right' caption='[[4ofh]], [[Resolution|resolution]] 2.22Å' scene=''> | <StructureSection load='4ofh' size='340' side='right' caption='[[4ofh]], [[Resolution|resolution]] 2.22Å' scene=''> | ||
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iho|3iho]], [[4ea5|4ea5]], [[4e9g|4e9g]], [[4e9e|4e9e]], [[4e9f|4e9f]], [[4ea4|4ea4]], [[4ofa|4ofa]], [[4ofe|4ofe]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iho|3iho]], [[4ea5|4ea5]], [[4e9g|4e9g]], [[4e9e|4e9e]], [[4e9f|4e9f]], [[4ea4|4ea4]], [[4ofa|4ofa]], [[4ofe|4ofe]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ofh RCSB], [http://www.ebi.ac.uk/pdbsum/4ofh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofh OCA], [http://pdbe.org/4ofh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ofh RCSB], [http://www.ebi.ac.uk/pdbsum/4ofh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofh ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | [[http://www.uniprot.org/uniprot/MBD4_HUMAN MBD4_HUMAN]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.<ref>PMID:10097147</ref> <ref>PMID:10930409</ref> | ||
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| + | ==See Also== | ||
| + | *[[Methyl CpG binding protein|Methyl CpG binding protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 00:12, 26 January 2017
Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications for roles of Arg468 in mismatch recognition and catalysis
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