IGF1

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Revision as of 15:01, 26 January 2017

Structural basis for IGF1 protein with N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE ligand

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↑ Patrick Jouandin. Rôle de la voie de signalisation Insuline dans le couplage des informations nutritionnelles et développementales au cours de l'ovogenèse chez la drosophile. Sciences agricoles.Université Nice Sophia Antipolis, 2013. Français.<NNT : 2013NICE4102>.<tel-00932409>

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 Insulin is a very important endocrine protein. Indeed, it is the only hypoglycemic hormone of the human body. This protein is secreted in the beta cells of the Langerhans’ islet in the pancreas and takes part in the glycogenesis. This molecule helps the transportation of glucose into the cells, thus reducing the blood sugar rate, contrary to glucagon.
-Insulin also has a huge effect on growth and thereby has a lot of structural similarities with its main associated growth factor: IGF-1. Both share lots of properties thanks to their 60% similarity.
+Insulin also has a huge effect on growth and thereby has a lot of structural similarities with its main associated growth factor: IGF-1, aka somatomedin. Both share lots of properties thanks to their 60% similarity.
 IGF-1 is a peptidic hormone of 69 amino acids which is secreted by the liver.
 This protein deals with a large scale of regulations, from growth to nutrition and it is even implied in stress response, breeding and longevity.<ref>Patrick Jouandin. Rôle de la voie de signalisation Insuline dans le couplage des informations nutritionnelles et développementales au cours de l'ovogenèse chez la drosophile.  Sciences agricoles.Université Nice Sophia Antipolis, 2013.  Français.<NNT : 2013NICE4102>.<tel-00932409></ref>.