1s2r
From Proteopedia
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|PDB= 1s2r |SIZE=350|CAPTION= <scene name='initialview01'>1s2r</scene>, resolution 1.53Å | |PDB= 1s2r |SIZE=350|CAPTION= <scene name='initialview01'>1s2r</scene>, resolution 1.53Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SPM:SPERMINE'>SPM</scene> | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2r OCA], [http://www.ebi.ac.uk/pdbsum/1s2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s2r RCSB]</span> | ||
}} | }} | ||
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[[Category: Williams, L D.]] | [[Category: Williams, L D.]] | ||
[[Category: Woods, K K.]] | [[Category: Woods, K K.]] | ||
| - | [[Category: SPM]] | ||
[[Category: dodecamer]] | [[Category: dodecamer]] | ||
[[Category: minor groove hydration]] | [[Category: minor groove hydration]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:32 2008'' |
Revision as of 20:36, 30 March 2008
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| , resolution 1.53Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2
Overview
The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
About this Structure
1S2R is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:15563130
Page seeded by OCA on Sun Mar 30 23:36:32 2008
