User:Olivier Laprevote/Sandbox 1
From Proteopedia
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[[Image:Vav_domains_-_Copie.png]] | [[Image:Vav_domains_-_Copie.png]] | ||
| - | The Vav1 <scene name='75/751211/Structure_vav/3'>structural domains</scene> are (from N ter to C ter): a '''calponin-homology''' (CH) domain, a '''DBL-homology''' (DH) domain also known as a '''rhoGEF''' domain, a '''pleckstrin-homology''' (PH) domain, a '''phorbol esters/diacylglycerol binding''' (C1) domain and '''Src-homology''' (SH) 3 and 2 domains. <ref>http://smart.embl.de/smart/show_motifs.pl?GENOMIC=1&DO_PFAM=DO_PFAM&INCLUDE_SIGNALP=INCLUDE_SIGNALP&ID=9606.ENSP00000472929</ref> | + | The Vav1 <scene name='75/751211/Structure_vav/3'>structural domains</scene> are (from N ter to C ter): a '''calponin-homology''' (CH) domain, an '''acidic''' (Ac) domain, a '''DBL-homology''' (DH) domain also known as a '''rhoGEF''' domain, a '''pleckstrin-homology''' (PH) domain, a '''phorbol esters/diacylglycerol binding''' (C1) domain and '''Src-homology''' (SH) 3 and 2 domains. <ref>http://smart.embl.de/smart/show_motifs.pl?GENOMIC=1&DO_PFAM=DO_PFAM&INCLUDE_SIGNALP=INCLUDE_SIGNALP&ID=9606.ENSP00000472929</ref> |
| - | <scene name='75/751211/Calponin-homology_domain/2'>Calponin-homology (CH) domain</scene> : When the CH domain is deleted, Vav has a phosphorylation-independant GEF activity. | + | <scene name='75/751211/Calponin-homology_domain/2'>Calponin-homology (CH) domain</scene> : When the CH domain is deleted, Vav has a phosphorylation-independant GEF activity. The conclusion is that the CH domain intervenes in the auto-inhibition of Vav. Studies on Vav3 implies that this is due to interactions from the CH domain with the Ac, DH and C1 regions.<ref>PMID:1142542</ref> |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:08, 26 January 2017
Proto-oncogene vav
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ http://www.uniprot.org/uniprot/P15498#function
- ↑ http://smart.embl.de/smart/show_motifs.pl?GENOMIC=1&DO_PFAM=DO_PFAM&INCLUDE_SIGNALP=INCLUDE_SIGNALP&ID=9606.ENSP00000472929
- ↑ Logan DT, Maurer D. Diversity of marine invertebrates in a thermal effluent. J Water Pollut Control Fed. 1975 Mar;47(3 PT 1):515-23. PMID:1142542
