Mitogen-activated protein kinase kinase kinase
From Proteopedia
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[[Image:2clq.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, [[2clq]]]] | [[Image:2clq.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, [[2clq]]]] | ||
| - | {{STRUCTURE_2o2v| right| PDB=2o2v | SCENE= |CAPTION=Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey), [[2o2v]] }} | ||
| + | <StructureSection load='2o2v' size='350' side='right' caption='Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code [[2o2v]]).' scene=''> | ||
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== Disease == | == Disease == | ||
MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer. | MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer. | ||
| - | + | </StructureSection> | |
== 3D Structures of Mitogen-activated protein kinase kinase == | == 3D Structures of Mitogen-activated protein kinase kinase == | ||
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*MAP3K7 | *MAP3K7 | ||
| - | **[[2eva]] – hMAP3K7/MAP3K7-interacting protein | + | **[[2eva]] – hMAP3K7/MAP3K7-interacting protein 1<br /> |
| + | **[[5gjd]], [[5gjf]], [[5gjg]], [[5e7r]], [[5jga]], [[5jgb]], [[5jgd]], [[4o91]], [[4l52]], [[4l53]], [[4l3p]], [[4gs6]], [[2y1y]] - hMAP3K7/MAP3K7-interacting protein 1 + inhibitor<br /> | ||
*MAP3K9 | *MAP3K9 | ||
Revision as of 09:44, 29 January 2017
Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, 2clq
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3D Structures of Mitogen-activated protein kinase kinase
Updated on 29-January-2017
References
- ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
