Mitogen-activated protein kinase kinase kinase

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[[Image:2clq.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, [[2clq]]]]
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<StructureSection load='2o2v' size='350' side='right' caption='Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code [[2o2v]]).' scene=''>
<StructureSection load='2o2v' size='350' side='right' caption='Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code [[2o2v]]).' scene=''>
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== Function ==
== Function ==
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**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br />
**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br />
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*MAP3K7
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*MAP3K7 (TAK1)
**[[2eva]] – hMAP3K7/MAP3K7-interacting protein 1<br />
**[[2eva]] – hMAP3K7/MAP3K7-interacting protein 1<br />

Revision as of 09:46, 29 January 2017


Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code 2o2v).

Drag the structure with the mouse to rotate

3D Structures of Mitogen-activated protein kinase kinase

Updated on 29-January-2017

References

  1. Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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