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Pleurotolysin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='4v3a' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus...) |
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| - | + | <StructureSection load='4v3a' size='340' side='right' caption='Pleurotoxin A (grey and green) complex with pleurotoxin B (pink) (PDB code [[4v3a]])' scene=''> | |
| - | <StructureSection load='4v3a' size='340' side='right' caption=' | + | |
== Function == | == Function == | ||
'''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. | '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. | ||
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| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:16, 1 February 2017
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3D structures of pleurotolysin
Updated on 01-February-2017
References
- ↑ Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y. Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem. 2004 Jun 25;279(26):26975-82. Epub 2004 Apr 14. PMID:15084605 doi:http://dx.doi.org/10.1074/jbc.M402676200
