1s4j
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1s4h|1S4H]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4j OCA], [http://www.ebi.ac.uk/pdbsum/1s4j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s4j RCSB]</span> | ||
}} | }} | ||
| Line 30: | Line 33: | ||
[[Category: ribosomal p2 protein]] | [[Category: ribosomal p2 protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:37:13 2008'' |
Revision as of 20:37, 30 March 2008
| |||||||
| Related: | 1S4H
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of cross-reactive peptides from Homo sapiens
Overview
The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
About this Structure
1S4J is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012
Page seeded by OCA on Sun Mar 30 23:37:13 2008
