5tvn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the LSD-bound 5-HT2B receptor== | |
| - | + | <StructureSection load='5tvn' size='340' side='right' caption='[[5tvn]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tvn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TVN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LD:(8ALPHA)-N,N-DIETHYL-6-METHYL-9,10-DIDEHYDROERGOLINE-8-CARBOXAMIDE'>7LD</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvn OCA], [http://pdbe.org/5tvn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tvn RCSB], [http://www.ebi.ac.uk/pdbsum/5tvn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvn ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Betz, R M]] | ||
| + | [[Category: Che, T]] | ||
| + | [[Category: Dror, R O]] | ||
| + | [[Category: Lansu, K]] | ||
[[Category: Levit, A]] | [[Category: Levit, A]] | ||
| - | [[Category: | + | [[Category: McCorvy, J D]] |
| - | [[Category: | + | [[Category: Nichols, D E]] |
| - | [[Category: Roth, B | + | [[Category: Roth, B L]] |
| - | [[Category: | + | [[Category: Schools, Z L]] |
| - | [[Category: | + | [[Category: Shoichet, B K]] |
| + | [[Category: Venkatakrishnan, A J]] | ||
[[Category: Wacker, D]] | [[Category: Wacker, D]] | ||
| - | [[Category: Mccorvy, J.D]] | ||
[[Category: Wang, S]] | [[Category: Wang, S]] | ||
| - | [[Category: | + | [[Category: Gpcr]] |
| + | [[Category: Lsd]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Serotonin receptor]] | ||
Revision as of 18:09, 1 February 2017
Crystal structure of the LSD-bound 5-HT2B receptor
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Categories: Betz, R M | Che, T | Dror, R O | Lansu, K | Levit, A | McCorvy, J D | Nichols, D E | Roth, B L | Schools, Z L | Shoichet, B K | Venkatakrishnan, A J | Wacker, D | Wang, S | Gpcr | Lsd | Membrane protein | Serotonin receptor
