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Hemolysin
From Proteopedia
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== Function == | == Function == | ||
'''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. | ||
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== Relevance == | == Relevance == | ||
HL acts as a virulence factor in the pathogenesis of invasive infections<ref>PMID:12564994</ref>. | HL acts as a virulence factor in the pathogenesis of invasive infections<ref>PMID:12564994</ref>. | ||
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== 3D Structures of hemolysin == | == 3D Structures of hemolysin == | ||
Revision as of 09:09, 7 February 2017
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3D Structures of hemolysin
Updated on 07-February-2017
A full page in Proteopedia exploring 7ahl is found here.
References
- ↑ Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774
- ↑ Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec;10(12):575-80. PMID:12564994
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