Cytolysin

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<StructureSection load='4owk' size='350' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code [[2edc]]).' scene=''>
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== Function ==
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'''Cytolysins''' are β-barrel pore-forming toxins secreted by a variety of organisms and causing cell lysis.
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== Structural highlights ==
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In the fluoroacetate dehalogenase complex with halide, the <scene name='59/594596/Cv/4'>iodide is seen in the active site cavity between two tryptophans</scene> (in cyan).<ref>PMID:8369276</ref>
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</StructureSection>
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==3D structures of dehalogenase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Anthrolysin O
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**[[3cqf]]– AntL – ''Bacillus anthracis''<br />
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* Cytolysin
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**[[4owj]] – VvCytL – ''Vibrio vulnificus''<br />
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**[[4owk]], [[4owl]] – VvCytL + saccharide<br />
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**[[4gx7]] – CytL + mannose – ''Vibrio cholerae''<br />
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* Equinatoxin II
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**[[1kd6]] – Equx – ''Actinia equina'' - NMR<br />
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* Fragaceatoxin C
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**[[3w9p]] – FraC – strawberry anemone<br />
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* Hemolysin see [[Hemolysin]]
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* Intermedilysin
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**[[5imt]] – IntL – ''Streptococcus intermedius''<br />
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* Listeriolysin O
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**[[4cdb]] – LisL 1-4 domain – ''Listeria monocytogenes''<br />
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* Lysenin
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**[[5ec5]] – Lys – red wiggler worm<br />
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* Perforin-1
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**[[4y1s]], [[4y1t]] – mPrf1 C2 domain – mouse<br />
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**[[3nsj]] – mPrf1 (mutant)<br />
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* Perfringolysin O
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**[[5dhl]], [[5dim]] – CpPerL (mutant) – ''Clostridium perfringens''<br />
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**[[1pfo]] – CpPerL <br />
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* Pneumolysin
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**[[5aod]], [[4zgh]], [[5cr6]], [[4qqa]] – SpPneL – ''Streptococcus pneumoniae''<br />
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**[[5aoe]], [[5aof]] – SpPneL (mutant)<br />
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**[[5cr8]] – SpPneL membrane-binding domain<br />
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**[[4qqq]] – SpPneL + mannose<br />
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**[[2bk1]], [[2bk2]] – SpPneL - CryoEM<br />
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* Sticholysin
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**[[1o71]], [[1gwy]] – saStiL-2 – sea anemone <br />
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**[[2l2b]] – saStiL-2 - NMR<br />
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**[[2l38]] – saStiL-2 (mutant) - NMR<br />
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**[[1o72]] – saStiL-2 + phosphorylcholine<br />
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**[[2ks4]] – saStiL-1 - NMR<br />
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* Stonustoxin
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**[[4wvm]] – Stnx – stonefish<br />
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* Streptolysin O
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**[[4hsc]] – StrL – ''Streptococcus pyogenes''<br />
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}}
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== References ==
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<references/>
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[[Category:Topic Page]]

Revision as of 09:36, 7 February 2017

Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc).

Drag the structure with the mouse to rotate

3D structures of dehalogenase

Updated on 07-February-2017

References

  1. ↑ Verschueren KH, Kingma J, Rozeboom HJ, Kalk KH, Janssen DB, Dijkstra BW. Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site. Biochemistry. 1993 Sep 7;32(35):9031-7. PMID:8369276

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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