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Revision as of 21:23, 7 February 2017
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Contents |
DNA Helicase
DNA Helicase is a complex, 14 chain structure that unwinds DNA in replication by cleaving the hydrogen bonds between the complementary nucleotides at the replication fork. It is present in both prokaryotes and eukaryotes.
Function
By cleaving the hydrogen bonds between the complementary nucleotides at the , Helicase allows DNA polymerase to have access to each DNA strand in order to replicate each strand. Aside from its part in DNA replication, it also functions to unwind DNA in repair, transcription, and recombination.
Disease
Malfunctioning Helicase causes issues in each of its functions. With regard to transcription, it can cause mutations of all sorts, including missense and nonsense substitutions as well as frameshift and deletion mutations. Without Helicase, the DNA helix remains locked with Hydrogen bonds and DNA polymerase does not have access to either strand.
Structural highlights
There are several ligands that bind the various chains together in order to create Helicase. In various places throughout Helicase, a acts as a ligand.
