1sbu
From Proteopedia
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|PDB= 1sbu |SIZE=350|CAPTION= <scene name='initialview01'>1sbu</scene> | |PDB= 1sbu |SIZE=350|CAPTION= <scene name='initialview01'>1sbu</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=2MT:(4R)-2,2-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>2MT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbu OCA], [http://www.ebi.ac.uk/pdbsum/1sbu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sbu RCSB]</span> | ||
}} | }} | ||
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[[Category: vi beta turn]] | [[Category: vi beta turn]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:40:06 2008'' |
Revision as of 20:40, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2
Overview
The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
About this Structure
1SBU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A case study of 2,2-dimethylthiazolidine as locked cis proline amide bond: synthesis, NMR and molecular modeling studies of a delta-conotoxin EVIA peptide analog., Chierici S, Jourdan M, Figuet M, Dumy P, Org Biomol Chem. 2004 Sep 7;2(17):2437-41. Epub 2004 Aug 5. PMID:15326523
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