Sandbox Reserved 1302
From Proteopedia
(→References) |
|||
| Line 5: | Line 5: | ||
==Origin== | ==Origin== | ||
Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, ''Xenopus laevis'', conducted in Aaron Klug's lab. | Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, ''Xenopus laevis'', conducted in Aaron Klug's lab. | ||
| + | |||
==Structure== | ==Structure== | ||
The “finger” refers to the secondary structures (<scene name='75/751195/Alpha_helix/1'>α-helix</scene> and β-sheet) that are held together by the <scene name='75/751195/Sandbox_zinc/2'>Zinc ion</scene>. | The “finger” refers to the secondary structures (<scene name='75/751195/Alpha_helix/1'>α-helix</scene> and β-sheet) that are held together by the <scene name='75/751195/Sandbox_zinc/2'>Zinc ion</scene>. | ||
| + | |||
==Function== | ==Function== | ||
Revision as of 21:07, 8 February 2017
Contents |
Zinc-finger 1
|
Origin
Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, Xenopus laevis, conducted in Aaron Klug's lab.
Structure
The “finger” refers to the secondary structures ( and β-sheet) that are held together by the .
Function
This small protein motif is a transcriptional regulator. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. regulate eukaryotic gene expression
Interactions
The zinc-fingers usually interact with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix.
References
Zinc Fingers. (n.d.). Retrieved February 08, 2017, from http://www.ebi.ac.uk/interpro/potm/2007_3/Page2.htm
