Sandbox Reserved 1265
From Proteopedia
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<StructureSection load='3j8c' size='340' side='right' caption='View of the full octamer complex''> | <StructureSection load='3j8c' size='340' side='right' caption='View of the full octamer complex''> | ||
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| + | <scene name='75/751158/Subunit_polypeptides/1'>This view indicates the directional conformation of each subunit's primary structure.</scene> | ||
==Function== | ==Function== | ||
Revision as of 21:14, 8 February 2017
Human Pre-initiation Complex (3j8c)
Structure
Human Pre-initiation complex is an octameric molecule - it is composed of 8 polypeptide chain subunits.
The 43S initiation complex forms when Methionine initiation tRNA (Met-tRNAi(Met)) forms a ternary complex with Eukaryotic Initiation factor 2 (EIF2) and GTP. This complex then binds to the 40S subunit of the ribosome alongside EIF3, EIF1, and EIF1A. Finally, DHX29, a protein that aids structured mRNA scanning, binds to the 40S subunit as well.
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