Sandbox Reserved 1302
From Proteopedia
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| - | ==Zinc-finger 1== | + | ==DNA Zinc-finger 1== |
<Structure load='1zaa' size='350' frame='true' align='right' caption='Here is a view of the 1zaa structure' scene='Insert optional scene name here' /> | <Structure load='1zaa' size='350' frame='true' align='right' caption='Here is a view of the 1zaa structure' scene='Insert optional scene name here' /> | ||
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This small protein motif is a transcriptional regulator that regulates eukarotic gene expression. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3', or EGR-site. DNA Zinc-fingers activate the transcription of target genes with products that are needed for mitogenesis (the induction of mitosis) and differentiation. | This small protein motif is a transcriptional regulator that regulates eukarotic gene expression. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3', or EGR-site. DNA Zinc-fingers activate the transcription of target genes with products that are needed for mitogenesis (the induction of mitosis) and differentiation. | ||
| - | ==Interactions== | ||
| + | ==Interactions== | ||
Zinc fingers are found in eukaryotic nucleus interacting with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix. | Zinc fingers are found in eukaryotic nucleus interacting with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix. | ||
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==References== | ==References== | ||
Revision as of 21:19, 8 February 2017
Contents |
DNA Zinc-finger 1
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Origin
Zinc fingers were first identified in a study of transcription in the transcription factor TFIIIA of the African clawed frog, Xenopus laevis, conducted in Aaron Klug's lab.
Structure
The “finger” refers to the secondary structures ( and ) that are held together by the .
Function
This small protein motif is a transcriptional regulator that regulates eukarotic gene expression. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3', or EGR-site. DNA Zinc-fingers activate the transcription of target genes with products that are needed for mitogenesis (the induction of mitosis) and differentiation.
Interactions
Zinc fingers are found in eukaryotic nucleus interacting with the outside of B-DNA. When interacting with DNA, the zinc fingers bind in the major groove of B-DNA and wrap part way around the double helix.
References
Zinc Fingers. (n.d.). Retrieved February 08, 2017, from http://www.ebi.ac.uk/interpro/potm/2007_3/Page2.htm
Miller, J., McLachlan, A. D., & Klug, A. (1985, June). Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. Retrieved February 08, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC554390/
Group, P. F., Motif, A., E., Highlights, C., & G. (n.d.). EpiGenie Learning Center. Retrieved February 08, 2017, from http://epigenie.com/key-epigenetic-players/chromatin-modifying-and-dna-binding-proteins/zinc-finger-proteins/
RCSB Protein Data Bank, Pavletich, N.P., Pabo, C.O. (n.d.). 1ZAA. Retrieved February 08, 2017, from http://www.rcsb.org/pdb/explore.do?structureId=1ZAA
