Sandbox Reserved 1265
From Proteopedia
(Difference between revisions)
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<StructureSection load='3j8c' size='340' side='right' caption='View of the full octamer complex''> | <StructureSection load='3j8c' size='340' side='right' caption='View of the full octamer complex''> | ||
| - | <scene name='75/751158/Subunit_polypeptides/1'>This view indicates the directional conformation of each subunit's primary structure.</scene> | + | <scene name='75/751158/Subunit_polypeptides/1'>This view indicates the directional conformation of each subunit's primary structure, with each polypeptide's 5' N-terminus marked in blue, and the 3' H-terminus marked in red.</scene> |
==Function== | ==Function== | ||
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The assembly and operation of Human PIC occurs entirely in the cytosol. | The assembly and operation of Human PIC occurs entirely in the cytosol. | ||
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| + | <scene name='75/751158/Alpha_helices/1'>As seen in the red ball-and-stick subunit, the alpha helices take on a very ordered, parallel orientation in most of the subunits, similar in many respects to transmembrane proteins, which may affect how they interact.</scene> | ||
== Origin == | == Origin == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J8C | ||
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| + | http://www.proteopedia.org/wiki/index.php/3j8c | ||
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| + | http://www.rcsb.org/pdb/explore.do?structureId=3j8c | ||
Revision as of 21:29, 8 February 2017
Human Pre-initiation Complex (3j8c)
Structure
Human Pre-initiation complex is an octameric molecule - it is composed of 8 polypeptide chain subunits.
The 43S initiation complex forms when Methionine initiation tRNA (Met-tRNAi(Met)) forms a ternary complex with Eukaryotic Initiation factor 2 (EIF2) and GTP. This complex then binds to the 40S subunit of the ribosome alongside EIF3, EIF1, and EIF1A. Finally, DHX29, a protein that aids structured mRNA scanning, binds to the 40S subunit as well.
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